Harris has made history as the first female, first Black and first South Asian American vice president. She served as a United States senator from 2017 until this year, and ran for president in 2020, but dropped out during the Democratic primary. She was the first woman and first Black woman to serve as California’s attorney general. She was the first Black woman from California to serve in the US Senate, and second from any state, after Illinois' Carol Moseley Braun. Harris was also the first person of Indian descent to appear on a presidential ticket. She is the daughter of immigrants to the United States from Jamaica and India.

Blinken served in the Obama administration as the deputy secretary of state, assistant to the president and principal deputy national security adviser. He served as the national security adviser to Biden when he was vice president and was a deputy assistant to the president during Obama's first term.

Yellen is the first woman to serve as Treasury secretary. Yellen already made history as the first woman to have chaired the Federal Reserve. She previously served as the vice chair of the board, and president and chief executive officer of the Federal Reserve Bank of San Francisco. Yellen was also chair of the White House Council of Economic Advisers from 1997 to 1999.

Austin is the first Black person to lead the Pentagon. Austin was approved for a congressional waiver to be confirmed for the civilian post because federal law requires seven years of retirement from active duty before taking on the role. Austin retired from active-duty service only four years ago. He is a retired Army general and served as the commander of the US Central Command.

Garland was most recently a federal judge on the US Court of Appeals for the DC Circuit, and was appointed by President Bill Clinton in 1997. President Barack Obama nominated Garland to the Supreme Court after a vacancy was created by the death of Justice Antonin Scalia in 2016. But Republicans, led by Senate Majority Leader Mitch McConnell, refused for months to hold confirmation hearings or the required vote in the chamber. Garland previously served as principal associate deputy attorney general.

Haaland is the first-ever Native American Cabinet secretary. Haaland had already made history in 2018 when she was elected as one of the first two Native American women in Congress. In 2016, Haaland traveled to North Dakota to take part in the protests over plans to build a pipeline underneath a key source of water for the Standing Rock Reservation.

Vilsack served as agriculture secretary for the entirety of President Barack Obama's time in the White House. Vilsack is also the former governor of Iowa — in 1998, he became the first Democrat elected governor of the state in more than 30 years.

Raimondo is the first woman to be governor of Rhode Island and had served since 2015. Raimondo was elected to serve as general treasurer of Rhode Island in 2010. She co-founded Point Judith Capital, an early stage venture capital firm.

Walsh has served as mayor of Boston since 2014 and is a veteran union operative. He led Boston's Building and Construction Trades Council, a group that represents ironworker and electrician unions, among others. Walsh's selection is a victory for AFL-CIO President Richard Trumka, who rallied his federation of 56 unions to back the Boston mayor soon after Biden won the election.

Becerra is the first Latino to lead the Department of Health and Human Services. He most recently served as California's attorney general, and was the first Latino to hold that office in the history of the state. As the state’s attorney general, Becerra had been a chief defender of the Affordable Care Act in court. Becerra served 12 terms in Congress as a member of the US House of Representatives.

Fudge had represented Ohio's 11th Congressional District since 2008. She previously chaired the Congressional Black Caucus. Prior to running for Congress, Fudge made history as the first woman and first African American to be elected mayor of Warrensville Heights, Ohio.

Buttigieg made history as the first out LGBTQ Cabinet secretary approved by the Senate. The former South Bend, Indiana, mayor is the youngest member nominated for Biden's Cabinet, at 38 years old. The former mayor is seen as a rising star in the Democratic Party and rose to national prominence during the 2020 Democratic primary.

Granholm served two terms as governor of Michigan, and was the first woman to be elected governor of the state. In that role, Granholm worked closely with the auto industry, the dominant industry in the Great Lakes State, which could help Biden as he attempts to move the country toward electric vehicles. Granholm was also the first woman to serve as Michigan’s attorney general.

Cardona, whose parents moved from Puerto Rico to Connecticut, is a high-profile Latino serving in Biden’s Cabinet. Cardona has been a leading proponent of sending children back to school, saying too many students are falling behind during virtual learning amid the coronavirus pandemic. Most recently, he served as Connecticut's commissioner of education.

McDonough served as chief of staff during Obama's entire second term, and also worked as deputy national security adviser. He chaired the National Security Council's Deputies Committee, which is responsible for formulating the administration's national security and foreign policy. McDonough also previously served as the chief of staff for the national security staff and as the deputy national security adviser for strategic communications.

Mayorkas is the first Latino and immigrant as secretary of the Department of Homeland Security. He was deputy secretary of Homeland Security during the Obama administration, and served as the director of the DHS's United States Citizenship and Immigration Services. Mayorkas oversaw the implementation of the Deferred Action for Childhood Arrivals program, which was an executive action under Obama that protected young undocumented immigrants who came to the US as children from deportation.

Klain is one of Biden's most trusted advisers, and served as Biden’s chief of staff when he was vice president in the Obama administration. Klain brings unique expertise to a moment defined by the coronavirus pandemic — he was appointed by then-President Barack Obama to lead the response to the Ebola crisis in 2014. Klain previously served as chief of staff to Vice President Al Gore during the Clinton administration, and has been the go-to operative for debate preparation for Democratic candidates dating as far back as Bill Clinton.

Regan is the first African American man to lead the EPA. Regan previously served as the secretary of North Carolina’s Department of Environmental Quality. He led the Environmental Defense Fund's efforts to combat the impacts of the climate crisis and air pollution, and worked at the EPA during the Clinton and Bush administrations.

Tanden would have been the first woman of color and first South Asian American to become director of the Office of Management and Budget, but the White House withdrew her nomination on March 2 when it became clear she did not have the votes to be confirmed. Tanden faced fierce opposition from Senate Republicans and some Democrats over past statements on social media. She is the CEO and president of the left-leaning Center for American Progress, and served in the Obama and Clinton administrations, and is expected to have a role in Biden's administration.

Tai is the first woman of color to serve as US trade representative. She was most recently the top Democratic trade counsel for the House Ways and Means Committee. Tai's nomination is seen as a clear sign that Biden is serious about his campaign promise to enforce trade rules on China. She is considered an expert on China trade policy and oversaw trade enforcement for China during the Obama administration.

Guzman most recently served as the director of California's Office of the Small Business Advocate, a government office that works to support and grow small businesses in America's most populous state. Before that, Guzman was the deputy chief of staff and senior adviser at the Small Business Administration, the office she now leads. Before her career in public service, Guzman was a small business entrepreneur.

Haines is the first woman to serve as director of national intelligence. She served as assistant to the president and principal deputy national security adviser to Obama. Haines previously served as the deputy director of the Central Intelligence Agency.

Thomas-Greenfield is a career diplomat who returns to public service after retiring from a 35-year career with the US Foreign Service in 2017. Greenfield held several posts in the Obama administration, including assistant secretary for the Bureau of African Affairs, director general of the Foreign Service and director of human resources. She has served as an ambassador to Liberia, and has also been posted to Switzerland, Pakistan, Kenya, The Gambia, Nigeria and Jamaica.

Rouse would be the first woman of color to chair the Council of Economic Advisers if confirmed by the Senate. Rouse previously served as a member of Obama's Council of Economic Advisers. She also worked at the National Economic Council in the Clinton administration as a special assistant to the president.

Kerry’s appointment as Biden’s special presidential envoy for climate underscores Biden’s commitment to tackling the global crisis. Kerry has long worked on climate issues, and as secretary of state during the Obama administration, he played a key role in negotiating the Paris agreement. In 2019, Kerry co-founded a bipartisan initiative of world leaders and celebrities to combat the climate crisis called World War Zero. Kerry will also sit on the National Security Council.

Lander directs the Office of Science and Technology Policy and serves as a presidential science adviser, a position that Biden has elevated to Cabinet-level for the first time. Lander served as external co-chair of the President's Council of Advisors on Science and Technology during the Obama administration. He helped lead the Human Genome Project, and is the president and founding director of the Broad Institute of MIT and Harvard, a non-profit biomedical research institute.