Martha Wayles Skelton Jefferson —
Martha Wayles Skelton Jefferson was the wife of the third US president, Thomas Jefferson, but she never actually served as first lady during his administration.
She died in 1782, roughly 20 years before her husband took office. After he was elected, their daughter Martha "Patsy" Jefferson Randolph is credited as filling the role of hostess in her mother's place during his term from 1801 to 1809, with assistance from future first lady Dolley Madison.